October 7, 2013 – Berkeley, California, U.S. – FILE – Nobel Prize in Physiology or Medicine 2013 goes jointly for discoveries of machinery regulating vesicle traffic, a major transport system in our cells. RANDY SCHEKMAN discovered a set of genes that were required for vesicle traffic. J. Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. T. Sudhof revealed how signals instruct vesicles to release their cargo with precision. PICTURED: Randy W. Schekman professor of molecular and cell biology at the University of California, Berkley, in his lab. (Credit Image: © Mark Richards/ZUMA Wire/ZUMAPRESS.com)